A Novel Biomarker SNHG11 Promotes Tumor Progression and Oxidative Phosphorylation in Clear Cell Renal Cell Carcinoma

• SNHG11 is identified as a methylation-associated lncRNA significantly correlated with poor prognosis in clear cell renal cell carcinoma (KIRC). • Functional assays demonstrate that SNHG11 promotes tumor proliferation and progression in vitro and in vivo. • Mechanistically, SNHG11 enhances oxidative phosphorylation, evidenced by increased ATP production, disrupted mitochondrial membrane potential, and altered NAD+/NADH ratios. • SNHG11 expression is associated with somatic mutations in BAP1 and PBRM1, suggesting crosstalk between epigenetic regulation and genetic alterations.