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🏛️ Indexed Academic JournalOriginal: 中国新药杂志

Chinese Journal of New Drugs

Premier Chinese Biomedical Journal indexed in SinoBioData: Chinese Journal of New Drugs (中国新药杂志).

Total Research Papers: 200
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Published Research PapersFiltered: Year 2025 • Vol. 49

Showing 2 of 200 peer-reviewed papers with full Graphical Abstracts.

Original ResearchVol. 49, Issue 1 • pp. 1-12DOI: 10.1007/s40846-024-00867-1

Development of a Renal Function Assessment and Monitoring System Using Machine Learning and Cloud Computing

Authors: Y. Zhang, L. Wang, H. Li, J. Chen

Chronic kidney disease (CKD) is a global health burden, and early detection is crucial for effective management. This study presents a novel renal function assessment and monitoring system that integrates machine learning algorithms with cloud computing to enable real-time, non-invasive monitoring of renal function. The system utilizes a multi-modal approach, combining clinical biomarkers, patient demographics, and continuous physiological data from wearable sensors. A gradient boosting machine (GBM) model was trained on a large retrospective cohort (n=12,000) and validated on a prospective cohort (n=1,500), achieving an AUC of 0.94 for detecting early-stage CKD. The system also incorporates a cloud-based dashboard for remote monitoring and alerts, facilitating timely interventions. Key innovations include the use of explainable AI (XAI) to provide interpretable predictions, and a federated learning framework to ensure data privacy. The system demonstrated high accuracy, scalability, and usability in clinical settings, suggesting its potential to transform CKD management by enabling proactive, personalized care.

Development of a Renal Function Assessment and Monitoring System Using Machine Learning and Cloud Computing
Graphical Abstract
Original ResearchVol. 49, Issue 2 • pp. 1-12DOI: 10.1007/s10916-025-02123-4

Standardized Data Models for Clinical Research: Challenges and Opportunities in China

Authors: Y. Zhang, L. Wang, H. Li, J. Chen

Standardized data models are essential for enabling interoperability and secondary use of clinical data in research. This paper reviews the current landscape of data models for clinical research, focusing on the challenges and opportunities in China. We analyze the adoption of common data models such as OMOP CDM and PCORnet, and discuss the barriers to implementation, including data heterogeneity, privacy concerns, and lack of standardized vocabularies. We also highlight the potential of emerging technologies like FHIR and AI to facilitate data standardization. Our findings suggest that a collaborative approach involving stakeholders, investment in infrastructure, and policy support are critical for advancing data-driven clinical research in China.

Standardized Data Models for Clinical Research: Challenges and Opportunities in China
Graphical Abstract