Original ResearchVol. 45, Issue 3 • pp. 123-145DOI: 10.1007/s12345-024-01234-5
Adverse Drug Reactions: A Comprehensive Review of Epidemiology, Mechanisms, and Clinical Management
Authors: John A. Smith, Emily R. Johnson, Michael T. Brown, Sarah L. Davis
Adverse drug reactions (ADRs) represent a significant challenge in clinical practice, contributing to patient morbidity, mortality, and healthcare costs. This comprehensive review synthesizes current knowledge on the epidemiology, underlying mechanisms, and clinical management of ADRs. We discuss classification systems, risk factors, and the role of pharmacogenomics in predicting susceptibility. Evidence-based strategies for prevention, detection, and reporting are highlighted, along with emerging digital health tools. The review emphasizes a multidisciplinary approach to mitigate ADR burden and improve patient safety.
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