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Protected by Google reCAPTCHA v3.•Privacy•Terms Key Findings in This Report
• USR is overexpressed in hepatocellular carcinoma and correlates with poor patient survival.
• Silencing USR reduces HCC cell proliferation, migration, and invasion while promoting apoptosis.
• USR stabilizes β-catenin via deubiquitination, activating oncogenic Wnt signaling.
• Targeting USR suppresses tumor growth in vivo, highlighting its therapeutic potential.