Official PDF Translation•Acta Biochimica et Biophysica Sinica

Zinc finger protein 154 inhibits the growth and metastasis of cervical cancer cells through inhibiting Wnt/β-catenin signaling by upregulating NLK

Authors: Chulan Yang; Hongyu Zhao; Jing Tuo; Wei Zhao; Zhiwei Zhang; Zemin Pan; Lianghai Wang; Haixuan Zhao; Songhua Zhao; Hongtao Li

DOI: 10.3724/abbs.2025118Status: Verified Translated Edition

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Key Findings in This Report

• ZNF154 is downregulated in cervical cancer via promoter methylation, correlating with poor prognosis. • Overexpression of ZNF154 suppresses cervical cancer cell proliferation and migration. • ZNF154 inhibits Wnt/β-catenin signaling by upregulating NLK, a novel mechanistic link. • ZNF154 represents a potential therapeutic target for cervical cancer treatment.