Official PDF Translation•Acta Biochimica et Biophysica Sinica

USP18-stabilized ELF3 drives glycolysis and malignant progression in lung adenocarcinoma

Authors: ZENG Yu; YI Yeran; ZHANG Qinfen; LI Li; ZHAO Xiaohe; JIN Haixia; HUANG Ziqi; GUO Shiwei; WANG Qiyu; SHEN Meng; LI Baihui; YANG Lili; ZHAO Weipeng

DOI: 10.3724/abbs.2026082Status: Verified Translated Edition

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Key Findings in This Report

• ELF3 is overexpressed in LUAD tissues and correlates with poor prognosis. • ELF3 promotes LUAD cell proliferation, migration, invasion, and glycolysis via transcriptional regulation of HK2 and GLUT1. • USP18 deubiquitinates and stabilizes ELF3, enhancing its oncogenic effects. • Dacinostat, a small-molecule inhibitor targeting ELF3, suppresses LUAD malignant progression.