TRMT13 inhibits the growth of papillary thyroid cancer by targeting ANAPC4

• TRMT13 and ANAPC4 are downregulated in papillary thyroid cancer (PTC) tissues and cell lines, with expression levels positively correlated. • TRMT13 suppresses PTC cell proliferation, migration, and invasion, and ANAPC4 is a downstream target mediating these effects. • In a nude mouse xenograft model, both TRMT13 and ANAPC4 inhibit tumor growth, and their expression levels correlate with patient survival. • The study reveals a novel tumor-suppressive role for TRMT13 in PTC, linking tRNA methyltransferase and coiled-coil domain-containing protein families to cancer biology.