Official PDF Translation•Acta Biochimica et Biophysica Sinica

Transcriptional Regulation of GPSM2 by ZNF263 in Colorectal Cancer: Implications for Tumor Aggressiveness

Authors: SHI Youquan; BARAL Shantanu; ZHANG Youlei; JIANG Yongjun; LI Ruiqi; ZHANG Yue; WANG Wei; WANG Daorong

DOI: 10.3724/abbs.2025181Status: Verified Translated Edition

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Key Findings in This Report

• ZNF263 transcriptionally regulates GPSM2 expression in colorectal cancer. • ZNF263 promotes CRC cell proliferation, migration, and invasion via GPSM2-dependent activation of the cell cycle pathway. • Bioinformatics analysis of GEO datasets identifies GPSM2 and ZNF263 as key genes in CRC progression. • Targeting ZNF263 and GPSM2 may offer novel therapeutic strategies for colorectal cancer.