• The United States leads in total knee arthroplasty alignment research, with the University of California as the top institution and Howell, Stephen M as the most prolific author.
• Kinematic alignment and robotic navigation are emerging as key research hotspots in total knee arthroplasty alignment techniques.
• Despite advances in computer-assisted navigation and patient-specific instrumentation, no optimal alignment technique has been universally accepted.
• Future research should focus on robot-assisted navigation, patient satisfaction, long-term survival, and patient-specific alignment to improve outcomes.
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