• Isoniazid liposomes were successfully prepared with encapsulation efficiency of 28.67% and drug loading of 3.54%, and incorporated into 3D-printed photothermal scaffolds.
• Incorporation of isoniazid liposomes increased scaffold porosity but decreased compressive strength and elastic modulus, yet still meeting minimum requirements for in vivo implantation.
• Isoniazid liposome doping effectively mitigated drug burst release in the early phase, with cumulative release inversely proportional to liposome content; 808 nm NIR irradiation enhanced later-stage drug release.
• All scaffolds exhibited good cytocompatibility with MC3T3 cells, with relative proliferation rates >70% at 24, 72, and 120 hours.