• NRIP1 is significantly overexpressed in AML and correlates with poor overall survival, establishing it as a prognostic biomarker.
• NRIP1 expression is associated with infiltration of multiple immune cell types, suggesting a role in modulating the tumor immune microenvironment.
• Functional studies demonstrate that NRIP1 knockdown suppresses AML cell proliferation and induces apoptosis, validating its oncogenic role.
• NRIP1 may regulate ferroptosis and metabolic reprogramming, offering new therapeutic avenues for AML treatment.