The effect of liver-specific ketohexokinase deletion on the intestinal-liver-kidney axis in high-fructose-induced metabolic syndrome mice

• Liver-specific KHK deletion alleviates liver injury, hepatic steatosis, and hypertriglyceridemia in high-fructose-fed mice. • Hepatic KHK deficiency reduces uric acid levels and xanthine oxidase activity in plasma, urine, liver, and kidneys. • Liver KHK deletion inhibits fructose absorption and metabolism in intestine and kidneys by downregulating KHK, Glut2, Glut5, and aldolase B expression. • Liver-specific KHK knockout improves adipose tissue remodeling and reduces inflammation, protecting against fructose-induced metabolic syndrome.