The effect of exogenous mitochondria in enhancing the survival and volume retention of transplanted fat tissue in a nude mice model

• Exogenous mitochondrial preconditioning significantly improves the retention of mass and volume in transplanted fat grafts in a nude mouse model. • Mitochondria-treated fat grafts exhibit superior structural morphology and integrity compared to controls, indicating enhanced graft survival. • The study provides evidence that mitochondrial augmentation can mitigate ischemic and hypoxic damage to adipocytes, addressing a major challenge in fat grafting. • These findings suggest a promising clinical strategy to optimize fat grafting outcomes in plastic and reconstructive surgery.