Official PDF Translation•Stem Cell Research & Therapy

Targeting prominin-2/BACH1/GLS pathway to inhibit oxidative stress-induced ferroptosis of bone mesenchymal stem cells

Authors: Yuzhu Xu; Lele Zhang; Xuanfei Xu; Yuao Tao; Pengfei Xue; Yuntao Wang; Renjie Chai; Xiaotao Wu

DOI: 10.1186/s13287-025-04326-1Status: Verified Translated Edition

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Key Findings in This Report

• HSF1 transcriptionally activates PROM2, elevating Prominin-2 expression to protect BMSCs from ferroptosis. • Prominin-2 promotes BACH1 ubiquitination and degradation, reversing TBHP-induced downregulation of GLS. • Targeting the Prominin-2/BACH1/GLS axis enhances BMSC survival post-transplantation and mitigates IVDD progression. • Provides novel mechanistic insights and potential therapeutic targets for improving BMSC-based IVDD therapy under oxidative stress.