Official PDF Translation•Acta Biochimica et Biophysica Sinica

Suppression of pancreatic cancer proliferation through TXNIP-mediated inhibition of the MAPK signaling pathway

Authors: Qinglin Fei; Kaizhou Jin; Saimeng Shi; Tianjiao Li; Duancheng Guo; Mengxiong Lin; Xianjun Yu; Weiding Wu; Longyun Ye

DOI: 10.3724/abbs.2023286Status: Verified Translated Edition

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Key Findings in This Report

• High TXNIP expression correlates with improved overall survival in pancreatic cancer patients. • Overexpression of TXNIP suppresses proliferation and migration of pancreatic cancer cells in vitro. • TXNIP inhibits the MAPK signaling pathway, particularly via dephosphorylation of Erk1/2. • TXNIP emerges as a novel prognostic marker and potential therapeutic target for pancreatic cancer.