SUN5 interacts with TRIM28, enhancing IκBα ubiquitination to promote glycolysis in colorectal cancer cells

• SUN5 overexpression enhances glycolysis in colorectal cancer cells, while knockdown reduces it. • SUN5 interacts with TRIM28 to promote IκBα ubiquitination, activating NF-κB signaling. • NF-κB activation upregulates GLUT1 and LDHA, accelerating glycolysis and tumor growth. • SUN5 is a potential therapeutic target for colorectal cancer diagnosis and treatment.