Research on the Mechanism of Action of a Novel Drug for the Treatment of Peripheral Neuropathy

• NSPQ significantly reduces mechanical allodynia and thermal hyperalgesia in a rat model of chronic constriction injury, indicating potent analgesic effects. • The compound modulates neuroinflammation by downregulating pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and upregulating anti-inflammatory IL-10 in dorsal root ganglia and spinal cord. • NSPQ enhances the expression of neurotrophic factors BDNF and GDNF, which are critical for neuronal survival and regeneration. • These findings support NSPQ as a promising candidate for the treatment of peripheral neuropathy, with potential for clinical translation.