Official PDF Translation•Stem Cell Research & Therapy

Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT

Authors: Qing Lin; Yunfei Ji; Bin Yang; Rongjia Zhu; Ping Song; Robert chunhua Zhao

DOI: 10.1186/s13287-026-04964-zStatus: Verified Translated Edition

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Key Findings in This Report

• MSCs alleviate IMQ-induced psoriasis by upregulating serine metabolism and the key enzyme PSPH. • PSPH enhances PINK1-Parkin-mediated mitophagy, which inhibits NLRP3 inflammasome activation in psoriatic keratinocytes. • MSCs reduce inflammatory cytokines and chemokines (IL-1β, IL-6, IL-8, TNF-α, MCP-1, CCL7, CCL20, CCL27) and restore skin barrier integrity. • PSPH knockdown reverses the therapeutic effects of MSCs, confirming its critical role in the pathway.