• Regenerative medicine demonstrates significant efficacy across multiple specific dermatologic disorders, with improvement rates up to 68.4% for androgenetic alopecia and 71% for vitiligo.
• Platelet-rich plasma (PRP) and autologous epidermal melanocyte/keratinocyte transplantation are the most commonly studied regenerative interventions for androgenetic alopecia and vitiligo, respectively.
• The systematic review of 64 RCTs (n=2888) reveals consistent effectiveness of regenerative therapies for conditions including alopecia areata, melasma, and acne vulgaris, with 100% of studies reporting positive outcomes for several diseases.
• The findings underscore the need for further large-scale clinical trials to validate and expand the application of regenerative medicine in dermatology, particularly for understudied conditions like lichen sclerosus et atrophicus.