Radiotherapy Combined with Concurrent Chemotherapy in the Treatment of Locally Advanced Cervical Cancer: A Systematic Review and Meta-Analysis

• Concurrent chemoradiotherapy significantly improves overall survival and progression-free survival in locally advanced cervical cancer compared to radiotherapy alone. • Cisplatin-based regimens and intensity-modulated radiotherapy (IMRT) are associated with better clinical outcomes. • CCRT increases the risk of grade 3-4 hematologic and gastrointestinal toxicities, which require proactive management. • These findings support CCRT as the standard of care for LACC, emphasizing the need for individualized treatment planning.