Official PDF Translation•Acta Biochimica et Biophysica Sinica

PRR34-AS1 promotes mitochondrial division and glycolytic reprogramming in hepatocellular carcinoma cells through upregulation of MIEF2

Authors: Xuejing Yang; Huijing Feng; Jonghwa Kim; Gang Ti; Lin Wang; Kun Wang; Dong Song

DOI: 10.3724/abbs.2024083Status: Verified Translated Edition

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Key Findings in This Report

• PRR34-AS1 is overexpressed in HCC and promotes proliferation, invasion, glycolysis, and mitochondrial division. • PRR34-AS1 acts as a ceRNA by sponging miR-498, leading to upregulation of MIEF2. • The PRR34-AS1/miR-498/MIEF2 axis drives glycolytic reprogramming and mitochondrial division, contributing to HCC progression. • Targeting this axis may offer novel therapeutic strategies for hepatocellular carcinoma.