Proteomic analysis of the mechanism of moxibustion intervention in a rat model of atopic dermatitis

• Moxibustion significantly reduces skin lesion severity in a rat model of atopic dermatitis, confirming its therapeutic efficacy. • Proteomic analysis identified 68 differentially expressed proteins reversed by moxibustion, highlighting its multi-target mechanism. • Key pathways involved include neuroactive ligand-receptor interaction, TRP channel regulation, and neutrophil extracellular trap formation. • Moxibustion modulates proteins such as integrin β3 and NF-κB subunit 1, suggesting anti-inflammatory and antioxidant actions.