Official PDF Translation•Chinese Journal of Tissue Engineering Research

Prostaglandin E1 pretreatment inhibits ferroptosis in endothelial cells in a rat model of spinal cord ischemia-reperfusion injury

Authors: Huang Yushan; Wang Rongrong; Li Xiangmiao; Bai Jinzhu

DOI: 10.12307/2026.21237Status: Verified Translated Edition

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Key Findings in This Report

• Prostaglandin E1 pretreatment attenuates spinal cord ischemia-reperfusion injury by inhibiting ferroptosis in endothelial cells. • The protective mechanism involves activation of the Nrf2/HO-1 signaling pathway. • Prostaglandin E1 reduces oxidative stress and lipid peroxidation, preserving blood-spinal cord barrier integrity. • Inhibition of Nrf2 with ML385 reverses the protective effects, confirming pathway specificity.