Preparation and Evaluation of Drug-Loaded Solid Lipid Nanoparticles for Enhanced Oral Bioavailability

• Solid lipid nanoparticles (SLNs) were successfully prepared using high-pressure homogenization, achieving a mean particle size of ~150 nm and high entrapment efficiency. • The optimized SLN formulation provided sustained drug release over 24 hours, indicating potential for reduced dosing frequency. • In vivo pharmacokinetic studies in rats showed a significant enhancement in oral bioavailability (approximately 2.5-fold) compared to the free drug. • SLNs offer a promising strategy for improving the oral delivery of poorly water-soluble drugs, with potential for clinical translation.