PPIA as a central regulator in a novel cell death pathway activated by iron homeostasis and redox disruption in multiple myeloma

• DHA induces ferroptosis in multiple myeloma by disrupting iron homeostasis and redox balance. • PPIA is a critical molecular target of DHA, linking iron/redox perturbation to ferroptotic cell death. • Combined DHA and erastin treatment synergistically inhibits MM growth. • DHA enhances T-cell activation and tumor suppression in a syngeneic mouse model.