Official PDF Translation•Acta Biochimica et Biophysica Sinica

PDK4-driven metabolic reprogramming enhances mesothelial cell invasion in colorectal cancer peritoneal metastasis

Authors: Lingyu Han; Qinyuan Zhang; Yuchen Wu; Wenqin Luo; Shaobo Mo; Hongsheng Fang; Qingguo Li; Renjie Wang; Guoxiang Cai; Weixing Dai

DOI: 10.3724/abbs.2025148Status: Verified Translated Edition

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Key Findings in This Report

• PDK4 is upregulated in mesothelial cells undergoing MMT in CRC peritoneal metastasis. • PDK4 promotes mesothelial cell invasion via increased fatty acid oxidation. • PDK4 enhances β-catenin acetylation, which is critical for mesothelial cell invasion. • Targeting PDK4 or FAO may offer therapeutic strategies to inhibit CRC peritoneal metastasis.