• PDK1 is upregulated in epithelial ovarian cancer (EOC) tissues and cell lines, correlating with poor prognosis.
• PDK1 promotes EOC cell proliferation, migration, and invasion by upregulating BGN expression and activating the NF-κB pathway.
• PDK1 and BGN interact in the cytoplasm, with PDK1 enhancing BGN mRNA stability.
• Targeting PDK1/BGN axis may offer novel therapeutic strategies and biomarkers for EOC diagnosis and treatment.