Official PDF Translation•Acta Biochimica et Biophysica Sinica

PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma

Authors: Meimei Cui; Xiaodi Ding; Yu Jiang; Liying Zhang; Wangkai Cao; Yongming Wang; Zhimei Sheng; Wei Sun; Ai Guo; Lihui Gu; Xiurong Zhang; Wanli Duan; Lihong Shi; Baogang Zhang

DOI: 10.3724/abbs.2025042Status: Verified Translated Edition

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Key Findings in This Report

• CAF-derived PDGFC is upregulated in LUAD and correlates with poor patient prognosis. • PDGFC promotes EMT and MMP2 expression via the PDGFRA-MAPK/ERK pathway. • PDGFC drives NF-to-CAF transformation and immunosuppressive TME remodeling. • PDGFC-induced PDGFRA upregulation creates positive feedback, suggesting a novel therapeutic target.