Official PDF Translation•Acta Biochimica et Biophysica Sinica

PCIF1 Modulates Glioblastoma Cell Migration and Invasion by Altering PI(3,4)P2 Levels through the PI5-Phosphatase INPP5B

Authors: MUSUNURU Preethi Priyanka; LI Yihan; ZHOU Yu; LIU Gai; SHA Zhuang; HU Zhiyuan; ZHOU Junbo; KONDURU Naveena; MENG Qingming; GAO Shangfeng; YU Rutong

DOI: 10.3724/abbs.2026027Status: Verified Translated Edition

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Key Findings in This Report

• PCIF1 suppresses glioblastoma cell migration and invasion by inhibiting EMT. • PCIF1 modulates AKT signaling via proteasomal degradation and phosphorylation. • PCIF1 regulates phosphoinositide levels through INPP5B, affecting PI(3,4)P2 and PI(3,4,5)P3. • PCIF1 is a potential biomarker and therapeutic target for glioblastoma.