Official PDF Translation•Acta Biochimica et Biophysica Sinica

P300-mediated H3K18 acetylation triggers necroptosis via modulation of KRT18 transcription in diabetic nephropathy

Authors: Qiao Zhao; Qinqin Cai; Aynigar Nizam; Qingxia Yang; Xu Liu; Fufen Meng; Zhipeng Meng

DOI: 10.3724/abbs.2026015Status: Verified Translated Edition

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Key Findings in This Report

• P300-mediated H3K18 acetylation upregulates KRT18 expression, driving necroptosis in diabetic nephropathy. • The P300-KRT18 axis activates the RIPK1/MLKL pathway, promoting tubular epithelial cell death. • Inhibition of P300 or KRT18 reduces necroptosis, offering a potential therapeutic strategy for DN. • Epigenetic regulation via histone acetylation emerges as a novel intervention target to delay DN progression.