Official PDF Translation•Stem Cell Research & Therapy

Overexpression of SOX4 in MSCs inhibits cellular senescence and enhances therapeutic efficacy in systemic lupus erythematosus

Authors: Jingjing Qi; Xiangge Zhao; Xiaoyu Gao; Xiaolu Zhu; Junli Wang; Jiaqing Liu; Jing Wei; Xia Li; Bihu Gao

DOI: 10.1186/s13287-025-04525-wStatus: Verified Translated Edition

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Key Findings in This Report

• SOX4 expression declines with MSC senescence, and its downregulation accelerates senescence while impairing immunosuppressive function. • Overexpression of SOX4 in late-passage MSCs reverses senescence markers and restores their immunosuppressive capacity. • SOX4-overexpressing MSCs show enhanced therapeutic efficacy in a mouse model of systemic lupus erythematosus. • Targeting SOX4 could improve the quality and therapeutic potential of MSCs for autoimmune disease treatment.