• PEEK@PDA-10Sr/HA-Ag coating significantly enhances MC3T3-E1 cell proliferation, adhesion, and osteogenic differentiation compared to unmodified PEEK.
• The composite coating exhibits strong antibacterial activity against both Escherichia coli and Staphylococcus aureus.
• Incorporation of strontium and silver ions into the polydopamine-hydroxyapatite coating improves hydrophilicity and surface roughness, promoting bioactivity.
• The multifunctional coating strategy offers a promising approach to overcome PEEK's bioinertness and infection risk in orthopedic and dental implants.