Official PDF Translation•Chinese Journal of Tissue Engineering Research

Non-coding RNA-activated by DNA damage promotes proliferation and inhibits apoptosis of induced pluripotent stem cell-derived cardiomyocytes

Authors: Huan Kanghui; Jiang Yujian; Bian Weihua

DOI: 10.12307/2026.21342Status: Verified Translated Edition

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Key Findings in This Report

• NORAD expression is significantly higher in neonatal mouse hearts compared to adult hearts, suggesting a role in cardiac development and regeneration. • Overexpression of NORAD in hiPSC-CMs enhances proliferation, as evidenced by increased Ki67 expression. • NORAD overexpression protects hiPSC-CMs from oxygen-glucose deprivation/reoxygenation-induced apoptosis by reducing ROS production and modulating apoptotic protein expression. • Transplantation of NORAD-overexpressing hiPSC-CMs improves cardiac function in a mouse model of myocardial infarction, highlighting its therapeutic potential.