Official PDF Translation•Acta Biochimica et Biophysica Sinica

NCOA6 knockdown enhances RSL3-induced ferroptosis in pancreatic cancer cells and increases the sensitivity to gemcitabine

Authors: Yuming Jia; Zeng Ye; Xin Wang; Yanli Deng; Chao Wang; Zhilei Zhang; Guixiong Fan; Wuhan Yang; Xiaowu Xu; Yi Qin; Li Peng

DOI: 10.3724/abbs.2024221Status: Verified Translated Edition

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Key Findings in This Report

• NCOA6 knockdown sensitizes pancreatic cancer cells to RSL3-induced ferroptosis and gemcitabine. • Mechanistically, NCOA6 knockdown upregulates ACSL4 and downregulates SCD1, altering lipid metabolism. • Clinical specimens confirm the inverse correlation between NCOA6 and ACSL4/SCD1 expression. • Targeting NCOA6 may overcome gemcitabine resistance in pancreatic cancer.