Official PDF Translation•Acta Biochimica et Biophysica Sinica

Natural product 2-dihydroailanthone suppresses colorectal cancer via targeting integrin α3

Authors: Yunjie Hu; Congcong Li; Yongjiang Wang; Wei Wang; Li Huang; Haoran Lei; Sijuan Sun; Lilian Zhao; Yuanping Liu; Yuting Mu; Zhuohong Li; Hongbin Cheng; Yucheng Gu; Shengxiong Huang; Dong Wang; Dale Guo; Yun Deng

DOI: 10.3724/abbs.2026045Status: Verified Translated Edition

Sponsored AdvertisementAd Placement Area

reCAPTCHA Bot Shield Active

Preparing Secure Academic Download

Verifying human reader & generating high-resolution document...

Verifying Document Integrity15s remaining

← Back to Article

Protected by Google reCAPTCHA v3.•Privacy•Terms

Sponsored ContentAdSense In-Feed Ad Slot

Key Findings in This Report

• 2-DAIL exhibits significant anti-CRC activity in vitro and in vivo. • 2-DAIL directly binds to integrin alpha-3 (ITGA3) as revealed by SILAC-TPP. • 2-DAIL blocks the PI3K/AKT signaling pathway mediated by ITGA3 inhibition. • 2-DAIL is a promising drug candidate for CRC treatment and other ITGA3-related diseases.