Official PDF Translation•Acta Biochimica et Biophysica Sinica

mTOR-related linc-PMB promotes mitochondrial biogenesis via stabilizing SIRT1 mRNA through binding to the HuR protein

Authors: Qian Chen; Huaying Zhang; Daokun Wang; Wenjing Liao; Yazhou Liu; Yurui Cai; Siyou Wang; Mengqian Yu

DOI: 10.3724/abbs.2024236Status: Verified Translated Edition

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Key Findings in This Report

• linc-PMB is a novel mTOR-associated lncRNA that promotes mitochondrial biogenesis. • linc-PMB stabilizes SIRT1 mRNA by binding to HuR, increasing SIRT1 expression. • The SIRT1/PGC-1α/mtTFA axis is activated by linc-PMB, enhancing mitochondrial function. • This pathway offers potential therapeutic targets for mitochondrial dysfunction-related diseases.