• miR-34b-3p is downregulated in cisplatin-resistant cervical cancer cells and tissues, and its overexpression suppresses proliferation, migration, invasion, and enhances chemosensitivity.
• STC2 and FN1 are identified as direct targets of miR-34b-3p, and their expression is elevated in resistant cells, contributing to chemoresistance and aggressive phenotypes.
• Rescue experiments confirm that STC2 or FN1 overexpression partially reverses the tumor-suppressive effects of miR-34b-3p, validating the miR-34b-3p/STC2/FN1 axis.
• The miR-34b-3p/STC2 or FN1 axis represents a potential therapeutic target for overcoming cisplatin resistance in cervical cancer patients.