• The microbiome in the female reproductive tract is crucial for conception and pregnancy outcomes, with dysbiosis linked to complications like GDM and preeclampsia.
• Restoring microbiome balance may improve fertility and ART success, offering potential for microbiome-based interventions.
• Microbial biomarkers show promise as indicators for early detection of pregnancy disorders.
• Comprehensive understanding of microbiome dynamics before and during pregnancy is essential for advancing ART and maternal-fetal health.
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