Official PDF Translation•Acta Biochimica et Biophysica Sinica

METTL3-mediated m6A modification facilitates Nectin-4-induced VNN1 upregulation and promotion of ESCC progression

Authors: Yuanfeng Long; Hang Yang; Ruolan Zhang; Quanneng Zhao; Mi Yang; Guiqin Song; Kang Liu

DOI: 10.3724/abbs.2025108Status: Verified Translated Edition

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Key Findings in This Report

• METTL3-mediated m6A modification stabilizes Nectin-4 mRNA, enhancing its expression in ESCC. • Nectin-4 promotes ESCC malignant phenotypes including proliferation, migration, and invasion. • VNN1 is identified as a downstream effector of Nectin-4, linking the METTL3/Nectin-4 axis to metabolic reprogramming. • The METTL3/Nectin-4/VNN1 axis offers novel biomarkers and therapeutic targets for ESCC.