Mechanism by which non-apoptotic regulated cell death induces neuronal injury in ischemic stroke

• Non-apoptotic regulated cell death (RCD) subroutines, including autophagy, ferroptosis, cuproptosis, disulfidptosis, necroptosis, and pyroptosis, play critical roles in neuronal injury after ischemic stroke. • Autophagy exhibits dual roles: neuroprotective during ischemia but detrimental during reperfusion due to excessive activation. • Ferroptosis and cuproptosis contribute to neuronal damage via iron overload, lipid peroxidation, and regulation of glutathione metabolism. • Targeting specific RCD pathways, such as pyroptosis and immunogenic cell death, offers novel therapeutic strategies for ischemic stroke.