• Matrine improves cardiac function and reduces myocardial injury in rats after myocardial infarction.
• Matrine promotes macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype.
• Matrine inhibits the JAK2/STAT3 signaling pathway, reducing inflammation and oxidative stress.
• The protective effects of matrine are dose-dependent, with higher doses showing greater efficacy.