Long noncoding RNA UCA1 knockdown inhibits cisplatin-resistant cervical cancer tumorigenesis via the miR-195-5p/IKBKB axis

• UCA1 is upregulated in cisplatin-resistant cervical cancer tissues and cells, promoting malignancy via miR-195-5p/IKBKB axis. • UCA1 knockdown inhibits proliferation, migration, invasion, and induces apoptosis in DDP-resistant HeLa cells. • UCA1 silencing suppresses tumor growth in vivo and modulates BNIP3/BNIP3Δex2 and NF-κB pathway. • The UCA1/miR-195-5p/IKBKB axis represents a promising therapeutic target for overcoming cisplatin resistance in cervical cancer.