Local administration of liposomal bupivacaine reduces postoperative pain and complications in spinal surgery: a meta-analysis

• Local application of liposomal bupivacaine in spinal surgery does not increase treatment-related complications. • Liposomal bupivacaine significantly reduces total opioid consumption after spinal surgery compared to controls. • No significant differences were found in pain scores at various follow-up points between liposomal bupivacaine and control groups. • The evidence is limited by the small number of included studies and the predominance of cohort studies; large randomized controlled trials are needed to confirm these findings.