lncRNA H19 facilitates vascular neointima formation by targeting miR-125a-3p/FLT1 axis

• lncRNA H19 overexpression promotes VSMC proliferation and migration, exacerbating neointima formation in a mouse carotid ligation model. • Mechanistically, lncRNA H19 acts as a ceRNA for miR-125a-3p, relieving its inhibition on FLT1 expression in VSMCs. • miR-125a-3p upregulation attenuates H19-induced VSMC proliferation and migration, and reduces FLT1 expression, suggesting a potential therapeutic axis. • Targeting lncRNA H19 or miR-125a-3p/FLT1 axis may offer a novel strategy for preventing vascular restenosis after angioplasty or stenting.