• LINC00365 promotes miR-221-5p expression by binding to Dicer, thereby inhibiting GSDMD and suppressing pyroptosis in colorectal cancer.
• GSDMD is identified as a direct target of miR-221-5p, linking the LINC00365/miR-221-5p axis to pyroptosis regulation.
• The study demonstrates that LINC00365 expression correlates with poor prognosis in colorectal cancer patients, suggesting its potential as a prognostic biomarker.
• Targeting the LINC00365/miR-221-5p/GSDMD pathway may offer a novel therapeutic strategy for colorectal cancer treatment.