LINC00114 promotes colorectal cancer metastasis by targeting HNRNPA1 to regulate glutamine metabolism reprogramming and angiogenesis

• LINC00114 and HNRNPA1 are overexpressed in colorectal cancer and positively correlate with CD31, a marker of angiogenesis. • Silencing LINC00114 inhibits CRC cell proliferation, metastasis, and HNRNPA1 expression, and suppresses HUVEC tubule formation. • LINC00114 binds to HNRNPA1 and regulates glutamine metabolism reprogramming, which is crucial for CRC metastasis. • In vivo, LINC00114 intervention represses tumor progression and vascular normalization, highlighting its potential as a therapeutic target.