Investigation of the cardioprotective potential of dantrolene in mitigating arsenic-induced cardiac dysfunction in rats

• Arsenic exposure significantly impairs myocardial perfusion and induces cardiac dysfunction in rats, as evidenced by reduced WIS and WIS × PI on myocardial contrast echocardiography. • Dantrolene treatment, particularly at high dose, effectively mitigates arsenic-induced myocardial injury and improves cardiac perfusion parameters. • The cardioprotective mechanism of dantrolene is attributed to its stabilization of RyR2, preventing pathological calcium leakage in cardiac myocytes. • These findings suggest dantrolene as a potential therapeutic agent for arsenic cardiotoxicity, warranting further clinical investigation.