• Interleukin-10 reduces inflammation in acute tendon injury by downregulating NF-κB, TNF-α, and COX-2 expression.
• IL-10 treatment improves tendon histological structure, reducing inflammatory cell infiltration and promoting tenocyte morphology recovery.
• Ultrasound imaging confirms that IL-10 restores tendon boundary clarity and thickness toward normal levels.
• IL-10 may serve as a potential therapeutic agent for managing acute tendon injuries by modulating the inflammatory response.