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Official PDF Translation•Chinese Journal of Tissue Engineering Research

Inhibitory effect of complement 1q/tumor necrosis factor-related protein 4 on 3T3-L1 preadipocyte differentiation

Authors: MaireyanmuĀ·Rozi; Wang Hongping; Zhang Cuiping; Xia Juan; Shen Tian; Lei Tao; Lu Jun; Gao Jie

DOI: 10.12307/2026.21334Status: Verified Translated Edition
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Key Findings in This Report

• CTRP4 inhibits 3T3-L1 preadipocyte differentiation into mature adipocytes. • CTRP4 downregulates key adipogenic transcription factors (C/EBPα, PPARγ) and FABP4. • CTRP4 reduces lipid accumulation and triglyceride/cholesterol levels in differentiating adipocytes. • CTRP4 may serve as a potential therapeutic target for obesity and metabolic disorders.