Official PDF Translation•Chinese Journal of New Drugs

Induced Pluripotent Stem Cells in the Treatment of Liver Disease: A Comprehensive Review

Authors: Research Collaborative Group

DOI: pub_80__articleID_50Status: Verified Translated Edition

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Key Findings in This Report

• iPSC-derived hepatocyte-like cells offer a promising cell source for liver disease modeling and drug screening. • Three-dimensional organoid cultures enhance the maturity and functionality of iPSC-derived liver cells. • Genetic correction of patient-specific iPSCs enables personalized cell therapy for inherited liver disorders. • Safety concerns, including tumorigenicity and immune rejection, remain major barriers to clinical application.